Volume 9 Number 3 (Jul. 2019)
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IJBBB 2019 Vol.9(3): 173-179 ISSN: 2010-3638
doi: 10.17706/ijbbb.2019.9.3.173-179

Analysis of Rescued Learning with Different Drugs in down Syndrome

Handan Kulan, Tamer Dağ
Abstract—Down syndrome (DS) affects approximately one in 700 live births and it is considered as the most prevalent cause of intellectual disability (ID). DS is caused by the presence of an extra copy of the human chromosome21 (Hsa21) and has been investigated on protein levels by using the Ts65Dn mouse model. For the treatment of DS, many efforts have been made for developing drugs to rescue learning performance. In this paper, we apply forward feature selection method to identify the important proteins in which memantine and GABAA alpha5 receptor inverse agonist- RO4938581 drugs affect. Identifying these gene products will help researchers to determine the molecular pathways which play key roles for rescuing performance in DS. Analyzing these pathways helps us to not only understand the learning process but also to contribute the new drug design for the treatment of DS.

Index Terms—Down syndrome, protein expression, memantine, RO4938581.

The authors are with Computer Engineering Department, Kadir Has University, Istanbul, Turkey (email: 20161102001@stu.khas.edu.tr).

Cite: Handan Kulan, Tamer Dağ, "Analysis of Rescued Learning with Different Drugs in down Syndrome," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 9, no. 3, pp. 173-179, 2019.

General Information

ISSN: 2010-3638 (Online)
Abbreviated Title: Int. J. Biosci. Biochem. Bioinform.
Frequency: Quarterly 
DOI: 10.17706/IJBBB
Editor-in-Chief: Prof. Ebtisam Heikal 
Abstracting/ Indexing:  Electronic Journals Library, Chemical Abstracts Services (CAS), Engineering & Technology Digital Library, Google Scholar, and ProQuest.
E-mail: ijbbb@iap.org
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