Volume 9 Number 1 (Jan. 2019)
Home > Archive > 2019 > Volume 9 Number 1 (Jan. 2019) >
IJBBB 2019 Vol.9(1): 35-41 ISSN: 2010-3638
doi: 10.17706/ijbbb.2019.9.1.35-41

Study of Calcium Distribution in Alzheimer’s Disease Using Finite Element Technique

Devanshi D. Dave, Brajesh Kumar Jha
Abstract—Alzheimer’s disease is the most common neurodegenerative disorder that is prevailing worldwide. Out of many reasons that may have their roles in prevailing this dementia, higher level of calcium concentration is one of them. There are various parameters that have their hands in maintaining the calcium level of the cytosol. Here we have taken into consideration the buffers and voltage gated calcium channel (VGCC) and used a two dimensional mathematical model to get the desired results. Finite element method (FEM) is employed to carry out the computations. Exogenous buffers like EGTA and BAPTA, which lower down the calcium concentration, have been used in addition to VGCC, which increases the calcium flux at the cytosolic level, to study the impact of calcium in Alzheimer’s disease. The obtained results show that there is increase in calcium concentration level of Alzheimer’s affected cell which render toxicity to the cell followed by cell death in AD.

Index Terms—Alzheimer’s disease, buffers, calcium, FEM, VGCC.

The authors are with Dept. of Mathematics, School of Technology, PDPU, Raisan, Gandhinagar-382007, Gujarat, India (email: ddave1822@gmail.com).

Cite: Devanshi D. Dave, Brajesh Kumar Jha, "Study of Calcium Distribution in Alzheimer’s Disease Using Finite Element Technique," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 9, no. 1, pp. 35-41, 2019.

General Information

ISSN: 2010-3638
Frequency: Bimonthly (2011-2015); Quarterly (Since 2016)
DOI: 10.17706/IJBBB
Editor-in-Chief: Prof. Ebtisam Heikal 
Abstracting/ Indexing: Electronic Journals Library, Chemical Abstracts Services (CAS), Google Scholar, and ProQuest.
E-mail: ijbbb@iap.org
  • Jan 11, 2019 News!

    The papers published in Vol. 9, No. 1 have all received dois from Crossref. [Click]

  • Jan 08, 2019 News!

    IJBBB Vol. 9, No. 1 has been published online! [Click]

  • Oct 08, 2018 News!

    The papers published in Vol. 8, No. 4 have all received dois from Crossref. [Click]

  • Jun 25, 2018 News!

    IJBBB Vol. 8, No. 4 has been published online!  [Click]

  • Apr 26, 2018 News!

    The papers published in Vol. 8, No. 3 have all received dois from Crossref. [Click]

  • Read more>>