Volume 8 Number 2 (Apr. 2018)
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IJBBB 2018 Vol.8(2): 107-116 ISSN: 2010-3638
doi: 10.17706/ijbbb.2018.8.2.107-116

Evaluation of Amino Acids Change in Structural Protein of Filoviridae Family during Evolution Process

Maryam Mohammadlou
Abstract—The likelihood ratios test results for VP24, VP30, VP35, and VP40 proteins of different species of Ebola viruses from Filoviridae family were determined using different models to obtain 2Δℓ values and to compare them with Chi-Square distribution 99% and 95%. Then, by using site models, BEB(Bayes Empirical Bayes) analysis gives positively selected sites of GP that are in the musin like domain. Results of likelihood ratio test using positive selection models lead to the conclusion that there are evidence for the relation between the change of amino acids in particular sites of structural proteins of this virus and increasing mortality rate of it.

Index Terms—Ebola virus, structural protein, likelihood ratios test, bayes empirical bayes.

The authors are with Science Faculty, I. Azad University, Ahar branch, Ahar, Iran (e-mail: mohammadlou.maryam@gmail.com).

Cite: Maryam Mohammadlou, "Evaluation of Amino Acids Change in Structural Protein of Filoviridae Family during Evolution Process," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 8, no. 2, pp. 107-116, 2018.

General Information

ISSN: 2010-3638
Frequency: Bimonthly (2011-2015); Quarterly (Since 2016)
DOI: 10.17706/IJBBB
Editor-in-Chief: Prof. Ebtisam Heikal 
Abstracting/ Indexing: Electronic Journals Library, Chemical Abstracts Services (CAS), Google Scholar, and ProQuest.
E-mail: ijbbb@iap.org
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