Volume 3 Number 4 (Jul. 2013)
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IJBBB 2013 Vol.3(4): 341-344 ISSN: 2010-3638
DOI: 10.7763/IJBBB.2013.V3.227

Bovine STAT5A Gene Polymorphism Analysis and Its Association with Milk Composition Traits in Jersey Cows

M. Selvaggi, V. Tufarelli, F. Pinto, G. Centoducati, A. Dambrosio, M. P. Santacroce, and C. Dario
Abstract—In mammals, the STAT proteins (signal transducers and activators of transcription) are a family of cytoplasmic transcription factors mediating the actions of many peptide hormones and cytokines within target cells. In particular, STAT5A is a crucial mediator in the lactogenic hormone response being a candidate marker for milk traits in farm animals. In the present paper, the T→C nucleotide polymorphism at position 12743 in exon 16 of the bovine STAT5A gene was analyzed with PCR-RFLP in a sample of Jersey cows. The purposes of this investigation were to determine the frequencies of the variant alleles and the genotypes of this SNP in Jersey cows and to verify its association with some milk production traits. All the three possible genotypes were identified in the studied population. The observed frequencies of C and T alleles were 0.147 and 0.853 repectively. The TT genotype was the most frequent followed by TC and CC ones. No significant differences between the TT and TC genotypes were found considering MY, FY PC and PY. On the other side, the difference concerning the fat content of milk produced by cows belonging to TC and TT groups was found significant at the statistical analysis: in particular, milk from TT animals had a higher fat content in comparison with that of TC ones (4.55 vs. 4.14%, respectively;P<0.05). However it may be necessary to carry out further investigations about this SNP to better clarify its role on milk production traits in cattle.

Index Terms—Jersey breed, milk production, SNP, STAT5A gene.

M. Selvaggi, V. Tufarelli, F. Pinto, A. Dambrosio, and C. Dario are with the Department DETO-Section of Veterinary Science and Animal Production, University of Bari “Aldo Moro”, Italy (e-mail: maria.selvaggi@uniba.it).
G. Centoducati is with the Department of Soil, Plant and Food, University of Bari “Aldo Moro”, Italy.
M. P. Santacroce is with the Department of Veterinary Medicine, University of Bari “Aldo Moro”, Italy.

 

Cite:M. Selvaggi, V. Tufarelli, F. Pinto, G. Centoducati, A. Dambrosio, M. P. Santacroce, and C. Dario, "Bovine STAT5A Gene Polymorphism Analysis and Its Association with Milk Composition Traits in Jersey Cows," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 3, no. 4, pp. 341-344, 2013.

General Information

ISSN: 2010-3638 (Online)
Abbreviated Title: Int. J. Biosci. Biochem. Bioinform.
Frequency: Quarterly 
DOI: 10.17706/IJBBB
Editor-in-Chief: Prof. Ebtisam Heikal 
Abstracting/ Indexing:  Electronic Journals Library, Chemical Abstracts Services (CAS), Engineering & Technology Digital Library, Google Scholar, and ProQuest.
E-mail: ijbbb@iap.org
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