Phenotypes Prediction from Gene Expression Data with Deep Multilayer Perceptron and Unsupervised Pre-training - Volume 8 Number 2 (Apr. 2018) - IJBBB
Volume 8 Number 2 (Apr. 2018)
Home > Archive > 2018 > Volume 8 Number 2 (Apr. 2018) >
IJBBB 2018 Vol.8(2): 125-131 ISSN: 2010-3638
doi: 10.17706/ijbbb.2018.8.2.125-131

Phenotypes Prediction from Gene Expression Data with Deep Multilayer Perceptron and Unsupervised Pre-training

Blaise Hanczar, Mathieu Henriette, Toky Ratovomanana, Farida Zehraoui
Abstract—Machine learning is widely used for phenotype prediction from gene expression data. However, deep learning, that is currently one of the most performant methods, have been very few studied for this problem. In this paper we construct a deep multilayer perceptron using different regularization methods to deal with the problem of small training samples. A large set of unlabeled data is used in an unsupervised pre-training procedure in order to improve the learning of the neural network. The results on several public microarray datasets show that the deep learning improves significantly the performance of the state-of-the-art.

Index Terms—Deep learning, phenotype prediction, gene expression data.

The authors are with IBISC, Univ. Evry, University Paris-Saclay, IBGBI, Bd de France, 91000 Evry, France (email: blaise.hanczar@ibisc.univ-evry.fr).

Cite: Blaise Hanczar, Mathieu Henriette, Toky Ratovomanana, Farida Zehraoui, "Phenotypes Prediction from Gene Expression Data with Deep Multilayer Perceptron and Unsupervised Pre-training," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 8, no. 2, pp. 125-131, 2018.

General Information

ISSN: 2010-3638
Frequency: Bimonthly (2011-2015); Quarterly (Since 2016)
DOI: 10.17706/IJBBB
Editor-in-Chief: Prof. Ebtisam Heikal 
Abstracting/ Indexing: Electronic Journals Library, Chemical Abstracts Services (CAS), Google Scholar, and ProQuest.
E-mail: ijbbb@iap.org
  • Jun 25, 2018 News!

    IJBBB Vol. 8, No. 4 has been published online!  [Click]

  • Apr 26, 2018 News!

    The papers published in Vol. 8, No. 3 have all received dois from Crossref. [Click]

  • Feb 24, 2018 News!

    IJBBB Vol. 8, No. 3 has been published online!  [Click]

  • Feb 06, 2018 News!

    The papers published in Vol. 8, No. 2 have all received dois from Crossref. [Click]

  • Jan 31, 2018 News!

    IJBBB Vol. 8, No. 2 has been published online!  [Click]

  • Read more>>