Volume 5 Number 4 (July 2015)
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IJBBB 2015 Vol.5(4): 211-220 ISSN: 2010-3638
doi: 10.17706/ijbbb.2015.5.4.211-220

Choline Phosphate Functionalized Cellulose Membrane Developed as Potential Hemostasis Dressing Based on a Unique Bioadhesion Mechanism

Xiaoqiang Yang, Na Li, Jayachandran N. Kizhakkedathu, Donald E. Brooks
Abstract—A choline phosphate functionalized biocompatible cellulose membrane that can efficiently arrest human red blood cells was developed to have potential application in wound dressing. The bioadhesion is based on the unique multivalent electrostatic interaction between the head groups of phosphatidyl choline based lipids on the cell membrane and its inverse orientation but virtually identical structure, choline phosphate, coupled to the cellulose membrane. For functionalization, the cellulose membrane was decorated with the polymer brushes bearing multiple choline phosphate groups via surface-initiator atom transfer radical polymerization followed by the click chemistry. The molecular weight and the grafting density of polymer brushes grafted from the cellulose membrane surface were thoroughly evaluated by force-distance measurements using atomic force microscopy. The dependence on the number density of choline phosphate groups and the grafting density of human red blood cell binding to the cellulose membrane surface is reported.

Index Terms—Bioadhesion, cellulose membrane, choline phosphate, wound dressing.

Centre for Blood Research, 2350 Health Sciences Mall, University of British Columbia, Vancouver V6T 1Z3, Canada.
School of Materials Science and Engineering, Zhengzhou University, Zhengzhou, China, 45000.
Department of Pathology and Laboratory of Medicine, Room G227-2211 Westbrook Mall, University of British Columbia, Vancouver V6T 2B5, Canada.

Cite: Xiaoqiang Yang, Na Li, Jayachandran N. Kizhakkedathu, Donald E. Brooks, "Choline Phosphate Functionalized Cellulose Membrane Developed as Potential Hemostasis Dressing Based on a Unique Bioadhesion Mechanism," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 5, no. 4, pp. 211-220, 2015.

General Information

ISSN: 2010-3638
Frequency: Bimonthly (2011-2015); Quarterly (Since 2016)
DOI: 10.17706/IJBBB
Editor-in-Chief: Prof. Ebtisam Heikal 
Abstracting/ Indexing: Electronic Journals Library, Chemical Abstracts Services (CAS), Google Scholar, and ProQuest.
E-mail: ijbbb@iap.org
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