Volume 5 Number 3 (May 2015)
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IJBBB 2015 Vol.5(3): 184-192 ISSN: 2010-3638
doi: 10.17706/ijbbb.2015.5.3.184-192

A Systematic Study of Functional Regulatory Modules by miRNA–miRNA Functional Synergistic Network in Hepatocellular Carcinoma

Xiangjun Kong, Xiaomei Geng, Junrui Zhao, Yuanjia Hu
Abstract—Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Poor understanding of the pathogenesis mechanism of HCC makes it difficult to be diagnosed and treated. The role of microRNAs (miRNAs) associated with progress and metastasis of HCC is emerging recently. For the purpose of systematically understanding the functional regulatory modules of miRNAs in HCC, this study constructed the miRNA-miRNA functional synergistic network (MFSN) based on KEGG pathway functional enrichment of co-targets collected from differentially expressed miRNAs related to HCC. To further understand the complex cooperative relations of miRNAs, two different synergistic subnetworks were generated to exhibit the effect of synergistic suppression of up-regulated miRNAs and synergistic enhancement of down-regulated miRNAs. Moreover, subnetworks of Focal adhesion, MAPK signaling pathway, Wnt signaling pathway, and TGF-beta signaling pathway were also extracted from MFSN to demonstrate synergistic influence profile of miRNAs in a specific functional pathway.

Index Terms—miRNA-miRNA functional synergistic network, hepatocellular carcinoma (HCC), differentially expressed miRNA, miRNA synergism.

Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau, China.

Cite: Xiangjun Kong, Xiaomei Geng, Junrui Zhao, Yuanjia Hu, "A Systematic Study of Functional Regulatory Modules by miRNA–miRNA Functional Synergistic Network in Hepatocellular Carcinoma," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 5, no. 3, pp. 184-192, 2015.

General Information

ISSN: 2010-3638 (Online)
Abbreviated Title: Int. J. Biosci. Biochem. Bioinform.
Frequency: Quarterly 
DOI: 10.17706/IJBBB
Editor-in-Chief: Prof. Ebtisam Heikal 
Abstracting/ Indexing:  Electronic Journals Library, Chemical Abstracts Services (CAS), Engineering & Technology Digital Library, Google Scholar, and ProQuest.
E-mail: ijbbb@iap.org
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