Volume 5 Number 3 (May 2015)
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IJBBB 2015 Vol.5(3): 157-164 ISSN: 2010-3638
doi: 10.17706/ijbbb.2015.5.3.157-164

Whole-Genome Analysis of Histone Marks Reveal Bivalent Promoter Dynamics upon Differentiation

Qingyan Li, Lin Li, Yong Yang, Xianhua Dai
Abstract—In ES cells, many promoters co-modified by the activating H3K4me3 mark and the repressive H3K27me3 mark. These bivalent domains are thought to play a pivotal role related to pluripotency by maintaining lineage commitment programs in a poised state. Enhancers are long-range regulatory elements that orcduring development and differentiation, which are marked by the presence of H3K4me1. However, how enhancers functional interact with bivalent promoters has remained unknown. In this paper, we found bivalent promoters are significantly flanked by poised enhancers which are distinguished by the enrichment of H3K4me1 and the absence of the H3K27ac in hESC. After differentiation of ESC to NPC, a neuron-specific subset of bivalent promoters acquires a chromatin signature with active modification marks.

Index Terms—Bivalent promoter, enhancer, association, H3K27me3.

School of Information Science and Technology, Sun Yat-Sen University, Guangzhou 510006, China.
College of Computer and Engineering, Jimei University, Xiamen 361021, China.
SYSU-CMU Shunde International Joint Research Institute, Shunde 528300, China.
School of Science, Jimei University, Xiamen 361021, China.

Cite: Qingyan Li, Lin Li, Yong Yang, Xianhua Dai, "Whole-Genome Analysis of Histone Marks Reveal Bivalent Promoter Dynamics upon Differentiation," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 5, no. 3, pp. 157-164, 2015.

General Information

ISSN: 2010-3638 (Online)
Abbreviated Title: Int. J. Biosci. Biochem. Bioinform.
Frequency: Quarterly 
DOI: 10.17706/IJBBB
Editor-in-Chief: Prof. Ebtisam Heikal 
Abstracting/ Indexing:  Electronic Journals Library, Chemical Abstracts Services (CAS), Engineering & Technology Digital Library, Google Scholar, and ProQuest.
E-mail: ijbbb@iap.org
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