Volume 5 Number 1 (Jan. 2015)
Home > Archive > 2015 > Volume 5 Number 1 (Jan. 2015) >
IJBBB 2015 Vol.5(1): 36-44 ISSN: 2010-3638
doi: 10.17706/ijbbb.2015.5.1.36-44

Assessment of Potential Toxicological Effects of Cinnamon Bark Aqueous Extract in Rats

Rabiatul Adawiyah Ahmad, Hamed Serati-Nouri, Fadzilah Adibah Abdul Majid, Mohamad Roji Sarmidi, Ramlan Abdul Aziz
Abstract—Cinnamon stick is world widely used in cooking, traditional medicine, perfumery and aesthetic industries. Many studies have demonstrated the potential of cinnamon extracts in diabetes treatment. Although it has been reported as safe in general cooking recipe and categorized as GRAS by USDA, sub-acute toxicity procedure was conducted in this study to determine effect of cinnamon extract on histopathological changes as well as the haematological parameters of blood. Water extraction was done for dried cinnamon. Twenty-four female Sprague Dawley rats were used in this study. The oral route was selected because it is the most likely route of human exposure through the consumption of herbs. The concentrations studied were 0.1, 0.5 and 2.0g/kg cinnamon aqueous extract (CE). There were no statistically significant effects of all concentrations of CE on behaviour, mortality, water intake, food consumption, weight gain, internal organs weight (liver and kidney) and heamatological parameters during treatment and post-treatment periods except: 1) the slight decreased in kidney and liver weight of rats treated with 0.5g/kg and 2) slight decreased in liver weight of rats treated with 2.0g/kg, during post-treatment period. Hence, these toxicity studies suggest that the CE is low to moderate in toxicity and CE below 0.5 g/kg dose level is safe to be used in the efficacy study especially for diabetes treatment.

Index Terms—Aqueous extract, cinnamon, histopathology, haematology.

Bioprocess Engineering Department, Faculty of Chemical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor, Malaysia(email: adibah@cheme.utm.my).
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran(email: Seratinourih@tbzmed.ac.ir).
Institute of Bioproduct Development, Universiti Teknologi Malaysia, 81310 Johor bahru, Johor, Malaysia.

Cite: Rabiatul Adawiyah Ahmad, Hamed Serati-Nouri, Fadzilah Adibah Abdul Majid, Mohamad Roji Sarmidi, Ramlan Abdul Aziz, "Assessment of Potential Toxicological Effects of Cinnamon Bark Aqueous Extract in Rats," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 5, no. 1, pp. 36-44, 2015.

General Information

ISSN: 2010-3638 (Online)
Abbreviated Title: Int. J. Biosci. Biochem. Bioinform.
Frequency: Quarterly 
DOI: 10.17706/IJBBB
Editor-in-Chief: Prof. Ebtisam Heikal 
Abstracting/ Indexing:  Electronic Journals Library, Chemical Abstracts Services (CAS), Engineering & Technology Digital Library, Google Scholar, and ProQuest.
E-mail: ijbbb@iap.org
  • Jun 25, 2021 News!

    IJBBB Vol 11, No 3 has been published online! [Click]

  • Mar 29, 2021 News!

    IJBBB Vol 11, No 2 has been published online!  [Click]

  • Dec 03, 2020 News!

    IJBBB Vol 11, No 1  has been published online! [Click]

  • Sep 28, 2020 News!

    IJBBB Vol 10, No 4 has been published online! [Click]

  • Jun 22, 2020 News!

    IJBBB Vol 10, No 3 has been published online! [Click]

  • Read more>>