Abstract—The nonlinearity parameter B/A is an important indicator of the nonlinear acoustical effects for biological tissues. This paper investigates nonlinear B/A parameter for biological tissues by using comparative method. The investigations are carried out in both computer simulation and phantom study. In simulation study, Pseudo-spectral time domain (PSTD) method for second-order acoustic equation with a novel un-split Perfectly Matched Layer is proposed to improve the simulation efficiency and meanwhile maintain high accuracy. In phantom study, an experimental platform based on the Ritec SNAP-5000 system is designed. Experiments in simulation and phantom study achieve high estimation accuracy for B/A with percentage error less than 3%. Experimental results show that the comparative method can provide accurate B/A measurement for biological tissues.

Index Terms—Acoustic Nonlinearity, B/A Parameter, Comparative method, Pseudo-spectral Methods.

The Department of Electronic Engineering, Fudan University, 220 Handan Road, Physics Building, 212, Shanghai, CN 200433 (email: jhyu@fudan.edu.cn).
The Key Lab of Medical Imaging Computing and Computer Assisted Intervention of Shanghai.

Cite: Jinhua Yu, Xue Cai,Yuanyuan Wang, Youneng Ma, "Simulation and Phantom Study of the Acoustic Nonlinear B/A Parameter for Biological Tissues by Using Comparative Method," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 4, no. 6, pp. 438-447, 2014.