Volume 4 Number 6 (Nov. 2014)
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IJBBB 2014 Vol.4(6): 438-447 ISSN: 2010-3638
doi: 10.17706/ijbbb.2014.4.6.438-447

Simulation and Phantom Study of the Acoustic Nonlinear B/A Parameter for Biological Tissues by Using Comparative Method

Jinhua Yu, Xue Cai,Yuanyuan Wang, Youneng Ma
Abstract—The nonlinearity parameter B/A is an important indicator of the nonlinear acoustical effects for biological tissues. This paper investigates nonlinear B/A parameter for biological tissues by using comparative method. The investigations are carried out in both computer simulation and phantom study. In simulation study, Pseudo-spectral time domain (PSTD) method for second-order acoustic equation with a novel un-split Perfectly Matched Layer is proposed to improve the simulation efficiency and meanwhile maintain high accuracy. In phantom study, an experimental platform based on the Ritec SNAP-5000 system is designed. Experiments in simulation and phantom study achieve high estimation accuracy for B/A with percentage error less than 3%. Experimental results show that the comparative method can provide accurate B/A measurement for biological tissues.

Index Terms—Acoustic Nonlinearity, B/A Parameter, Comparative method, Pseudo-spectral Methods.

The Department of Electronic Engineering, Fudan University, 220 Handan Road, Physics Building, 212, Shanghai, CN 200433 (email: jhyu@fudan.edu.cn).
The Key Lab of Medical Imaging Computing and Computer Assisted Intervention of Shanghai.

Cite: Jinhua Yu, Xue Cai,Yuanyuan Wang, Youneng Ma, "Simulation and Phantom Study of the Acoustic Nonlinear B/A Parameter for Biological Tissues by Using Comparative Method," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 4, no. 6, pp. 438-447, 2014.

General Information

ISSN: 2010-3638
Frequency: Bimonthly (2011-2015); Quarterly (Since 2016)
DOI: 10.17706/IJBBB
Editor-in-Chief: Prof. Ebtisam Heikal 
Abstracting/ Indexing: Electronic Journals Library, Chemical Abstracts Services (CAS), Engineering & Technology Digital Library, Google Scholar, and ProQuest.
E-mail: ijbbb@iap.org
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