Abstract—Normal pregnancy is associated with oxidative stress and this is even increased during preeclampsia (PE). The decrease in total antioxidant capacity is the pathophysiological basis for vitamin supplementation during pregnancy, but the beneficial effect of this approach is still unclear. Levels of creatinine, urea, cystatin, malondialdehyde (MDA), superoxide dysmutase activity (SOD), glutathione peroxidase (GSH-Px) activity and acidum ascorbicum were measured in the serums of all women. Mean MDA level in maternal plasma in normal pregnancies was significantly lower than in PE pregnancies (2,78 ±0.78 pmol/mg vs 3.20±0.91 pmol/mg, p< 0.05), as well as mean GSH-Px levels (811 ±206 U/l vs 1350±575 U/l, p< 0.05. Mean ascorbic acid values were significantly higher in normal than in PE pregnancies (9,85 ±2,43 mg/L vs 5.54±1.81 mg/L, p< 0.001), as well as mean SOD values (26.8 ±18.45% vs 12.3±10.3%, p< 0.001). There were no significant differences in normal pregnancy group with and without multivitamin supplementation. MDA levels were significantly lower in PE pregnancies with vitamin supplementation (2.99 ± 0.81 pmol/mg vs 3.42 ± 1.01 pmol/mg, p< 0.05), as well as GSC-Px levels (1200 ± 500 U/l vs 1500 ± 650 U/l, p< 0.05). Ascorbic acid values were significantly higher in the PE group with vitamin supplementation (6.16 ± 1.66 mg/L vs 4.92 ± 1.96 mg/L, p< 0.05), as well as SOD levels (13 ± 11.4 % vs 11.6 ± 9.2%, p< 0.001).

Index Terms—Preeclampsia, oxidative stress, vitamins, superoxide dismutase, creatinine, cystatine.

T. N. Ćebović is with the Biochemistry Department, Faculty of Medicine Novi Sad, University of Novi Sad, Clinical Centre of Vojvodina, Novi Sad, Vojvodina, Serbia (e-mail: cebovictatjana@gmail.com).
D. Marić is with the Department of Infectious Diseases, Faculty of Medicine, University of Novi Sad, Clinical Centre of Vojvodina, Novi Sad, Vojvodina, Serbia (e-mail: dijetinfo@gmail.com).
A. Nikolić is with the Department of Laboratory Diagnostics, Clinical Centre of Vojvodina, Novi Sad, Vojvodina, Serbia (e-mail: sanjaigaga@neobee.net).
A. Novakov-Mikić is with the Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Novi Sad, Clinical Centre of Vojvodina, Novi Sad, Vojvodina, Serbia (e-mail: aleksandranovakov@gmail.com).

 

Cite:Tatjana N. Ćebović, Daniela Marić, Aleksandra Nikolić, and Aleksandra Novakov-Mikić, "Antioxidant Status in Normal Pregnancy and Preeclampsia upon Multivitamin-Mineral Supplementation in the Region of Vojvodina," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 3, no. 2, pp. 138-144, 2013.