Relationship of Oxidative Stress with HIV Disease Progression in HIV/HCV Co-infected and HIV Mono-infected Adults in Miami
Abstract—Background: HIV and HCV infections are both characterized by increased oxidative stress. Information on the magnitude of this increase and its consequences in HIV/HCV co-infection and viral replication is limited. We investigated the relationship between oxidative stress and HIV-progression in HIV/HCV co-infected and HIV mono-infected adults.
Methods: 106 HIV/HCV co-infected and 115 HIV mono-infected participants provided demographic information and blood to determine 8-oxo-dG and percent oxidized glutathione.
Results: HIV/HCV co-infected subjects had higher percent oxidized glutathione, higher HIV viral load, lower mtDNA copies and higher liver fibrosis than mono-infected subjects. In a small sample of HIV/HCV co-infected participants with liver biopsy, 8-oxo-dG was significantly lower in participants with low fibrosis scores than those with high fibrosis scores, and the grade of inflammation was strongly associated with oxidized glutathione.
Conclusions: HIV/HCV co-infection seems to diminish the capacity of the antioxidant system to control oxidative stress, and increases HIV replication.
Index Terms—Glutathione (GSH), HIV/HCV co-infection, liver fibrosis index (FIB-4), oxidative stress.
Dong-Ho Shin, Sabrina S. Martinez, Mary Parsons, Adriana Campa, and Marianna K. Baum are with Florida International University, Miami FL 33199 USA (e-mail: firstname.lastname@example.org, email@example.com).
Dushyantha T. Jayaweera is with Jackson Memorial Hospital, University of Miami, Miami FL 33136-1096 USA.
Cite: Dong-Ho Shin, Sabrina S. Martinez, Mary Parsons, Dushyantha T. Jayaweera, Adriana Campa, and Marianna K. Baum, "Relationship of Oxidative Stress with HIV Disease Progression in HIV/HCV Co-infected and HIV Mono-infected Adults in Miami," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 2, no. 3, pp. 217-223, 2012.
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