Volume 2 Number 2 (Mar. 2012)
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IJBBB 2012 Vol.2(2): 126-130 ISSN: 2010-3638
DOI: 10.7763/IJBBB.2012.V2.85

Computational Studies on Effects of 1-(4-Chlorobenzylideneamino)-4-Phenyl-1H-Imidazol-2-Amine as an Anticancer Drug on DNA

Soroor Soraya and Seyed Sina Soraya

Abstract—Extensive studies conducted by investigators have led into discover of anticancer properties of compounds drived from Imidazole. Considering the fact that the series of compounds being new and the defects in the drugs available, which cause complications in the DNA string, the need for finding ways to cope that challenge is immiment. The value and the accuracy of computational methods, led us to choose the 4 nucleotides, Adenine, Cytosine, Guanine and Thymine as a measure of the DNA string and study the effect of the compound 1-(4-chlorobenzylideneamino)-4-phenyl-1H-imidazol-2-amine as a new biologic Imidazole anticancer drug, the medicinal effect of which has recently been established, on any of these DNA string nucleotides. The studies reveal the fact that the highest amount of interaction between the drug and the nucleotide is on Guanine. Then to conduct a through careful review, we checked all different constructible possibilities of drug containing (Imidazole ring, Phenyl and Chlorine atom) and Guanine nucleobase.

Index Terms—1-(4-chlorobenzylideneamino)-4-phenyl-1H-imidazol- 2-amine, nucleotide, nucleobase, anticancer drug.

Soroor Soraya is with the Basic Science Faculty, Department of Chemistry, Islamic Azad University, Neyriz Branch, Fars, Iran (corresponding author to provide phone: +987116274818; fax: +987116267974; e-mail: soroor_soraya@yahoo.com).
Seyed Sina Soraya is with the Department of IT and Computer Engineering, Shiraz University, Shiraz, Iran (e-mail: sorayya-sina@att.com).

Cite: Soroor Soraya and Seyed Sina Soraya, "Computational Studies on Effects of 1-(4-Chlorobenzylideneamino)-4-Phenyl-1H-Imidazol- 2-Amine as an Anticancer Drug on DNA," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 2, no. 2, pp. 126-130, 2012.

General Information

ISSN: 2010-3638
Frequency: Bimonthly (2011-2015); Quarterly (Since 2016)
DOI: 10.17706/IJBBB
Editor-in-Chief: Prof. Ebtisam Heikal 
Abstracting/ Indexing: Electronic Journals Library, Chemical Abstracts Services (CAS), Engineering & Technology Digital Library, Google Scholar, and ProQuest.
E-mail: ijbbb@iap.org
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