Volume 2 Number 2 (Mar. 2012)
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IJBBB 2012 Vol.2(2): 68-70 ISSN: 2010-3638
DOI: 10.7763/IJBBB.2012.V2.73

Study on Carbon Distribution at Protein Regions of Disorder

K. Akila, N. Sneha, and E. Rajasekaran

Abstract—Hydrophobic interaction is the dominant force in proteins that arises due to carbon. The content and distribution of this carbon make a protein to fold in some form to have a specific function. Diseased proteins are expectedly differing from this carbon distribution pattern. This is taken as focus of this work by taking neurodegenerative protein, the SOD for study. The carbon distribution analysis program is able to identify the disordered region clearly. A long stretch of hydrophilic/hydrophobic regions with different combination of amino acid is considered as disordered regions. This disorder is due to unfolding or misfolding. The program developd for this purpose can further analysis the proteins for identification of mutational sites for stabilisation.

Index Terms—Neurodegenerative disorder; SOD; card analysis; hydrophobicity; mutation; mutational site.

E. Rajasekaran and N. Sneha are with the Department of Bioinformatics, School of Biotechnology and Health Sciences, Karunya University, Karunya Nagar, Coimbatore-641114, Tamil Nadu, India (Tel.:+91-9524825876; e-mail:ersekaran@gmail.edu).
K. Akila is with the Bishop Heber College, Trichy-620 017.

Cite: K. Akila, N. Sneha, and E. Rajasekaran, "Study on Carbon Distribution at Protein Regions of Disorder," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 2, no. 2, pp.  68-70, 2012.

General Information

ISSN: 2010-3638
Frequency: Bimonthly (2011-2015); Quarterly (Since 2016)
DOI: 10.17706/IJBBB
Editor-in-Chief: Prof. Ebtisam Heikal 
Abstracting/ Indexing: Electronic Journals Library, Chemical Abstracts Services (CAS), Engineering & Technology Digital Library, Google Scholar, and ProQuest.
E-mail: ijbbb@iap.org
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