Abstract—Primary immunodeficiency diseases (PIDs) are complex and intrinsic genetic disorders that leads to immune dysfunction. We have developed “Resource of Asian Primary Immunodeficiency Diseases”, an open access database on PIDs. In the current study, we propose a heuristic approach of PID gene mutation data analysis based on the functional domain interactions. Through this approach, a list of functionally significant domains that disrupts PID genes’ protein-protein interactions(PPI) associated with disease mutation have been identified. Moreover, the domains to be associated with immune diseases and function based on observed PID gene mutations have also been prioritized for further molecular characterization of disease pathogenesis.

Index Terms—Domain-Domain Interactio, Disease Mutation, DIMA ,HitPredict.

Suresh Kumar Ramadoss. Author is with the Research Unit for Immunoinformatics, Research Center for Allergy and Immunology (RCAI), RIKEN Yokohama Institute, Japan.
Sujatha Mohan. Author (To whom correspondence should be addressed) is with the Research Unit for Immunoinformatics, Research Center for Allergy and Immunology (RCAI), RIKEN Yokohama Institute, Japan. Phone:+81-45-503-7034;Fax:+81-45-503-9694. Email: sujatha@rcai.riken.jp.

Cite: Suresh Kumar Ramadoss and Sujatha Mohan, "In Silico Identification of Prioritized Interacting Domains in Primary Immunodeficiency Disease Causing Genes," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 1, no. 2, pp. 84-88, 2011.