Abstract—Major depression is one of the typical psychiatric diseases. When psychiatric disease occurs, the function of brain cells may be influenced by some intestinal microbiota, which provides a pathway for the development of antidepressant drugs. The research on the correlation between microbiota and antidepressant has become a key issue in the treatment of major depression. This work explores the cell type specific gene interaction between microbiota and antidepressant drugs and isolates some potentially important genes that can be targets of further investigation in the mechanisms of how depressive related behaviours occur and act. Our analysis provides a deeper demonstration of the interaction between antidepressant and microbiota compared to original study, by means of an effective genetic matrix and PLS model.

Index Terms—Genetic correlation, microbiota, antidepressant drugs, PLS model.

Chutian Guo is with South Kensington Campus London SW7 2AZ, UK

Cite:Chutian Guo, "Cell Type Specific Gene Interaction between Microbiota and Antidepressant Drugs," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 11, no. 2, pp. 14-21, 2021.

Copyright © 2021 by the authors. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).